SV EN

2013

Grundforskning

(experimentell forskning, genetik, djurmodeller)

Akimoto C, Linder J, Nilsson A-C, Forsgren L, Alstermark H, Birve A, Andersen PM. No GGGGCC hexanucleotide repeat expansion in C9orf72 in patients with Parkinson’s Disease or Parkinsonisme. Amyotroph Lateral Scler Frontotemporal Degener 2013;14:26-29.

Brinkmalm G, Brinkmalm A, Bourgeois P, Persson R, Hansson O, Portelius E, Mercken M, Andreasson U, Parent S, Lipari F, Öhrfelt A, Bjerke M, Minthon L, Zetterberg H, Blennow K, Nutu M. Soluble Amyloid Precursor Protein α and β in CSF in Alzheimer’s Disease. Brain Res 2013;1513:117-126.

Chiang HH, Forsell C, Lilius L, Öijerstedt L, Thordardottir S, Shanmugarajan K, Westerlund M, Nennesmo I, Thonberg H, Graff C. Novel progranulin mutations with reduced serum-progranulin levels in frontotemporal dementia. Eur J Human Genetics, 2013;Mar 6.

Czell D, Andersen PM, Neuwirth C, Morita M, Weber M. Progressive aphasia as the presenting symptom in a patient with amyotrophic lateral sclerosis with a novel mutation in the OPTN gene. Amyotroph Lateral Scler Frontotemporal Degener 2013;14:138-140.

Czell D, Andersen PM, Morita M, Neuwirth C, Perren F, Weber M. Phenotypes in Swiss patients with familial ALS carrying TARDBP mutations. Neurodegener Dis 2013, E-pub Jan 10.

Dillman AA, Hauser DN, Gibbs JR, Nalls MA, McCoy MK, Rudenko IN, Galter D, Cookson MR. mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nature Neurosci. 2013 Apr;16(4):499-506

Eschbach J, Schwalenstöcker B, Soyal S, Bayer H, Wiesner D, Akimoto C, Nilsson A-C, Birve A, Meyer T, Dupuis L, Danzer K, Andersen PM, Witting A, Ludolph AC, Patsch W, Weydt P. PGC-1α is a sex-dependent modifier of human and experimental ALS. Hum Mol Genet 2013;22:3477-84.

Hedskog et al. Modulation of the ER-mitochondria interface in Alzheimer disease brain and related models. Proc Natl Acad Sci U S A. 2013 Apr 25

Hedskog et al. Biochemical studies of poly-T variants in the Alzheimer’s disease associated TOMM40 gene. J Alzheimer’s Dis. 2013;31(3):527-36

Hedskog L, Pinho CM, Filadi R, Rönnbäck A, Hertwig L, Wiehager B, Larssen P, Gellhaar S, Sandebring A, Westerlund M, Graff C, Winblad B, Galter D, Behbahani H, Pizzo P, Glaser E, Ankarcrona M. Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer’s disease and related models. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7916-21.

Hjorth E, Vedin I, Palmblad J, Cederholm T, Freund-Levi Y, Faxen Irving G, Wahlund L-O, Basun H, Eriksdotter M, Schultzberg M. Omega-3 fatty acids enhance phagocytosis of Alzheimer’s disease-related amyloid-β42 by human microglia and decrease inflammatory markers. J Alz Dis 2013;35:697–713

Ibáñez C, Simó C, Barupal DK, Fiehn O, Kivipelto M, Cedazo-Mínguez A, Cifuentes A. A new metabolomic workflow for early detection of Alzheimer’s disease. J Chromatogr A. 2013 Aug 9;1302:65-71

Ingre C, Landers JE, Rizik N, Akimoto C, Birve A, Keagle PJ, Piotrowska K, Press R, Andersen PM, Ludolph AC, Weishaupt JH. A novel phosphorylation site mutation in Profilin 1 revealed in a large screen of US, Nordic and German ALS/FTLD cohorts. Neurobiol Aging 2013;34:1708.e1-6

Ingre C, Pinto S, Birve A, Press R, Danielsson O, de Carvalho M, Guðmundsson G, Andersen PM. No association between VAPB mutations and familial or sporadic ALS in Sweden, Portugal and Iceland. ALS and FTD. Amyotroph Lateral Scler Frontotemporal Degener 2013 (epub August 23)

Karlsson T, Karlén A, Olson L, Josephson A. Neuronal over-expression of Nogo Receptor 1 in APPswe/PSEN1(dE9) mice impairs spatial cognition tasks without influencing plaque formation. J Alzheimer’s Dis 33, 145–155, 2013

Karlsson TE, Koczy J, Brené S, Olson L, Josephson A. Differential concerted activity induced regulation of Nogo receptors (1-3), LOTUS and Nogo mRNA in mouse brain. Plos One, 8, e60892, 2013

Olson L. Combinatory treatments needed for spinal cord injury. July 2, 2013 (Epub ahead of print) – A review that includes a discussion to the Nogo signaling system for CNS plasticity. Exp. Neurol.

Paus M, Kohl Z, Ben Abdallah NM, Galter D, Gillardon F, Winkler J. Enhanced dendritogenesis and axogenesis in hippocampal neuroblasts of LRRK2 knockout mice. Brain Res. 2013 Feb 25; 1497: 85-100.

Pihlstrøm L, Axelsson G, Bjørnarå KA, Dizdar N, Fardell C, Forsgren L, Holmberg B, Larsen JP, Linder J, Nissbrandt H, Tysnes OB, Ohman E, Dietrichs E, Toft M. Supportive evidence for 11 loci from genome-wide association studies in Parkinson’s disease. Neurobiol Aging, 34, 1708.e7-13, 2013.

Ran C, Willows T, Sydow O, Johansson A, Söderkvist P, Dizdar N, Ahmadi A, Olson L, Belin AC. The HLA-DRA variation rs3129882 is not associated with Parkinson’s Disease in Sweden. Parkinsonism Relat Disord. 2013 Jul;19(7):701-2

Ross JM*, Stewart JB*, Hagström E, Brene S, Mourier A, Coppotelli G, Freyer C, Lagouge M, Hoffer BJ, Olson L**, Larsson NG**. Germline mitochondrial DNA mutations aggravate ageing and can impair brain development. Nature. 2013 Aug 21. (*equal contributions)

Sandebring A, Welander H, Winblad B, Graff C, Tjernberg Lars O. The pathogenic Aβ43 is enriched in familial and sporadic Alzheimer disease. PLoS One. 2013;8(2).

Sarlus H, Wang X, Cedazo-Minguez A, Schultzberg M, Oprica M. Chronic airway-induced allergy in mice modifies gene expression in the brain toward insulin resistance and inflammatory responses. J Neuroinflam2013;10:99.

Schedin-Weiss S, Inoue M, Teranishi Y, Yamamoto NG, Karlström H, Winblad B, Tjernberg LO. Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation–application on γ-secretase. PLoS One. 2013 May 24;8(5):e63962.

Smith BN, Newhouse S, Vance C, Lee Y, Weale ME, Topp S, Millar J, Johnson L, Troakes C, Hortobagyi T, Al-Sarraj S, Rogelj B, Powell J, Lupton M, Lovestone S, Sapp P, Nestor PS, Schelhaas, Silani V, Gelera C, Van den Berg L, Veldink J, van Damme P, Robberecht W, de Jong V, Shaw PJ, Kirby J, Paul H, Morrison KE, Bass, Andersen PM, Landers J, Brown RH, Al-Chalabi A, Shaw CE. The C9ORF72 expansion mutation is derived from a single founder in European ALS/FTD patients and is highly unstable. Eur J Hum Genet 2013;21:102-108.

Van der Zee et al. A Pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability and intermediate repeats. Human Mutation, 2013;34:363-73.

Waibel S, Neumann M, Rosenbohm A, Birve A, Volk A, Weishaupt JH, Meyer T, Müller U, Andersen PM, Ludolph AC. Truncating mutations in FUS/TLS give rise to a more aggressive ALS-phenotype than missense mutations: A clinico-genetic study in Germany. Eur J Neurol 2013;20:540-546.

Wang K, Ju X, Wei L, Zuo X, Tia Y, Xie F, Hu P, Zhu C, Yu F, Meng Y, Wang H, Zhang F, Ma H, Ye R, Cheng H, Du J, Dong W, Zhou S, Wang C, Wang Y, Wang J, Chen X, Sun Z, Zhou N, Jiang Y, Liu X, Li X, Zhang N, Liu N, Guan Y, Han Y, Han Y, Lv X, Fu Y, Yu H, Xi C, Xie D, Zhao O, Xie P, Wang X, Zhang Z, Shen L, Cui Y, Yin X, Cheng H, Liang B, Zheng X, Lee TMC, Chen G, Zhou F, Veldink JH, Robberecht W, Landers J, Andersen PM, Al-Chalabi A, Shaw C, Liu C, Tang B, Xiao S, Robertson J, Fengyu Zhang F, van den Berg LH, Sun L, Liu J, Deng M, Yang S, Zhang X. Genome-wide association analyses in Chinese Han identify two new susceptibility loci for amyotrophic lateral sclerosis. Nat Genet 2013;45:697-700.

Weishaupt JH, Waibel S, Birve A, Volk AE, Mayer B, Meyer T, Ludolph AC, Andersen PM. A novel optineurin truncating mutation and three glaucoma-associated missense variants in patients with familial amyotrophic lateral sclerosis in Germany. Neurobiol Aging 2013;34:1516

Zheng L, Calvo-Garrido J, Hallbeck M, Hultenby K, Marcusson J, Cedazo-Minguez A, TermanA Intracellular Localization of Amyloid-β Peptide in SH-SY5Y Neuroblastoma Cells. J Alzheimers Dis. 2013 Jul 23.

 

Klinisk forskning

(diagnostik, behandling, kliniska prövningar, epidemiologi, neuropsykologi)

Berg AI, Wallin A, Nordlund A, Johansson B. Living with stable MCI: experiences among 17 individuals evaluated at a memory clinic. Aging Ment Health. 2013;17(3):293-9.

Billstedt E, Skoog I, Duberstein P, Hällström T, Andrén M, Björkelund C., Östling S, Waern, M. A 37 year prospective study of neuroticism and extroversion in women followed from mid-life to late life. Acta Psychiatr Scand. 2013 Feb 19.

Billstedt E, Waern M, Duberstein P, Marlow T, Hellström T, Ostling S, Skoog I Secular changes in personality: study on 75-year-olds examined in 1976-77 and 2005-2006. Int J Geriatr Psychiatry 2013;28:298-304.

Caracciolo B, Gatz M, Xu W, Marengoni A, Pedersen NL, Fratiglioni L. Relationship of subjective cognitive impairment and cognitive impairment no dementia to chronic disease and multimorbidity in a nation-wide twin study. J Alzheimers Dis. 2013 Jan 1;36(2):275-84.

Choo IH,Ni R, Schöll M et al. Combination of 18F-FDG PET and CSF biomarkers as a better predictor of the progression to Alzheimer Disease in MCI patients. J Alzheimer´s Dis, 2013:33:929-939.

Daborg J, Holmgren S, Abramsson A, Andreasson U, Zetterberg M, Nilsson S, Minthon L, Skoog I, Blennow K, Pekna M, Hanse E, Zetterberg H. Complement Gene Single Nucleotide Polymorphisms and Biomarker Endophenotypes of Alzheimer’s Disease. J Alzheimer’s Dis. 2013;35:51-7.

Eckerström C, Olsson E, Bjerke M, Malmgren H, Edman A, Wallin A, Nordlund A. A combination of neuropsychological, neuroimaging, and cerebrospinal fluid markers predicts conversion from mild cognitive impairment to dementia. J Alzheimer’s Dis. 2013 Jan 1;36(3):421-31

Eckerström M, Skoogh J, Rolstad S, Göthlin M, Steineck G, Johansson B, Wallin A. Sahlgrenska Academy Self-reported Cognitive Impairment Questionnaire (SASCI-Q)–a research tool discriminating between subjectively cognitively impaired patients and healthy controls. Int Psychogeriatr. 2013 Mar;25(3):420-30.

Edison P, Carter SF, Rinne JO et al. Comparison of MRI based and PET template based approaches in the quantitative analysis of amyloid imaging with PIB-PET. Neuroimage 2013: 70:423-433.

Ferencz B, Laukka EJ, Lövdén M, Kalpouzos G, Keller L, Graff C, Wahlund LO, Fratiglioni L, Bäckman L. The influence of APOE and TOMM40 polymorphisms on hippocampal volume and episodic memory in old age. Front Hum Neurosci. 2013 May 22;7:198.

Fredén Klenfeldt I, Karlsson B, Sigström R, Waern M, Östling S, Marlow T, Gustafson D, Skoog I. Prevalence of Obsessive-compulsive Disorder in Relation to Depression and Cognition in an Elderly Population. Am J Geriatr Psychiatry. 2013 Mar 13.

Guldberg-Kjär T, Sehlin S, Johansson B. ADHD symptoms across the lifespan in a population-based Swedish sample aged 65 to 80. Int Psychogeriatr. 2013 Apr;25(4):667-75

Hange D, Mehlig K, Lauren L, Guo X, Bengtsson C, Skoog I, Björkelund  C. Perceived mental stress in women associated with psychosomatic symptoms, but not mortality: observations from the Population Study of Women in Gothenburg. Int J Gen Med. 2013;6:307-15

Hjelm C, Broström A, Dahl A, Johansson B, Fredrikson M, Strömberg A. Factors Associated With Increased Risk for Dementia in Individuals Age 80 Years or Older With Congestive Heart Failure. J Cardiovasc Nurs. 2013 Jan 30. [Epub ahead of print]

Hörder H, Skoog I, Frändin K. Health-related quality of life in relation to walking habits and fitness: a population-based study of 75-year-olds. Qual Life Res. 2013 Aug;22(6):1213-23.

Irz X, Fratiglioni L, Kuosmanen N, Mazzocchi M, Modugno L, Nocella G, Shakersain B, Traill WB, Xu W, Zanello G. Sociodemographic determinants of diet quality of the EU elderly: a comparative analysis in four countries. Public Health Nutr. 2013 May 9:1-13

Jokinen H, Schmidt R, Ropele S, Fazekas F, Gouw AA, Barkhof F, Scheltens P, Madureira S, Verdelho A, Ferro JM, Wallin A, Poggesi A, Inzitari D, Pantoni L, Erkinjuntti T; LADIS Study Group. Diffusion changes predict cognitive and functional outcome: the LADIS study. Ann Neurol. 2013 May;73(5):576-83.

Johnell C, Religa D, Eriksdotter M. Dementia disorders and drug therapy: a nationwide study of over 7000 patients-data from SveDem. Ger Dem Cogn Disord 2013;35:239–248.

Jonsson Laukka E, Lövdén M, Herlitz A, Karlsson S, Ferencz B, Pantzar A, Keller L, Graff C, Fratiglioni L & Bäckman L. Genetic effects on old-age cognitive functioning: A population-based study. Psychology and Aging, 2013;28:262-274.

Kern S, Skoog I, Börjesson-Hanson A, Blennow K, Zetterberg H, Östling S, Kern J, Gudmundsson P, Marlow T, Rosengren R, Waern M. Lower CSF Interleukin-6 predicts future depression in a population-based sample of older women followed for 17 years. Brain Behav Immun. 2013 Aug;32:153-8.

Laukka EJ, Lövdén M, Herlitz A, Karlsson S, Ferencz B, Pantzar A, Keller L, Graff C, Fratiglioni L, Bäckman L. Genetic effects on old-age cognitive functioning: a population-based study. Psychol Aging. 2013 Mar;28(1):262-74.

Lövdén M, Jonsson Laukka E, Rieckmann A, Kalpouzos G, Li T-Q, Jonsson T, Wahlund LO, Fratiglioni L & Bäckman L. The dimensionality of between-person differences in white-matter microstructure in old age. Human Brain Mapping, 2013;34:1386-1398.

Magnusson K, Sehlin D, Syvänen S, Svedberg MM, Philipson O, Söderberg L, Tegerstedt K, Holmquist M, Gellerfors P, Tolmachev V, Antoni G, Lannfelt L, Hall H, Nilsson LN. Specific Uptake of an Amyloid-β Protofibril-Binding Antibody-Tracer in AβPP Transgenic Mouse Brain. J Alzheimer’s Dis. 2013 Jan 1;37(1):29-40.

Marutle A, Gillberg PG, Bergfors A et al. 3H-deprenyl and 3H-PIB autoradiography show different laminar distribution of astroglia and fibrillar ß-amyloid in Alzheimer brain. J Neuroinflammation 2013:10:90.

Mellqvist Fässberg M, Östling S, Börjesson-Hanson A, Skoog I, Waern M. Suicidal feelings in the twilight of life: A cross-sectional population-based study of 97-year-olds. BMJ Open. 2013 Feb 1;3(2).

Morin J, Wiktorsson S, Marlow T, Olesen PJ, Skoog I, Waern M. Alcohol use disorder in elderly suicide attempters: A controlled study. Am J Geriatr Psychiatry. 2013;21:196-203.

Ni R, Gillberg PG, Bergfors A et al. Amyloid tracers detect multiple binding sites in Alzheimer´s disease brain tissue. Brain 2013: 136: 2217-2227.

Nordberg A, Carter SF, Rinne J et al. European multi-center PET study of fibrillar amyloid in Alzheimer´s disease. Eur J Nucl Med Mol Imaging 2013: 40: 104-114.

Olsson E, Klasson N, Berge J, Eckerström C, Edman A, Malmgren H, Wallin A. White Matter Lesion Assessment in Patients with Cognitive Impairment and Healthy Controls: Reliability Comparisons between Visual Rating, a Manual, and an Automatic Volumetrical MRI Method-The Gothenburg MCI Study. J Aging Res. 2013;198471.

Papenberg G, Bäckman L, Nagel IE, Nietfeld W, Schröder J, Bertram L, Heekeren HR, Lindenberger U & Li S-C. (2013). Dopaminergic gene polymorphisms affect long-term forgetting in old age: Further support for the magnification hypothesis. J Cognitive Neuroscience, 25, 571-579.

Pedersen NL, Christensen K, Dahl AK, Finkel D, Franz CE, Gatz M, Horwitz BN, Johansson B, Johnson W, Kremen WS, Lyons MJ, Malmberg B, McGue M, Neiderhiser JM, Petersen I, Reynolds CA. IGEMS: the consortium on Interplay of Genes and Environment across Multiple Studies. Twin Res Hum Genet. 2013 Feb;16(1):481-9.

Piccinin AM, Muniz-Terrera G, Clouston S, Reynolds CA, Thorvaldsson V, Deary IJ, Deeg DJ, Johansson B, Mackinnon A, Spiro A 3rd, Starr JM, Skoog I, Hofer SM. Coordinated analysis of age, sex, and education effects on change in MMSE scores. J Gerontol B Psychol Sci Soc Sci. 2013 May;68(3):374-90.

Praetorius M, Thorvaldsson V, Hassing LB, Johansson B. Substantial effects of apolipoprotein E ε4 on memory decline in very old age: longitudinal findings from a population-based sample. Neurobiol Aging. 2013 Jul 12.

Prestia A, Caroli A, van der Flier V et al. Prediction of dementia in MCI patients based upon core diagnostic markers for Alzheimer´s disease. Neurology 2013:80:1-9.

Qiu C, von Strauss E, Bäckman L, Winblad B, Fratiglioni L.Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden. Neurology. 2013 May 14;80(20):1888-94.

Reynolds CA, Zavala C, Gatz M, Vie L, Johansson B, Malmberg B, Ingelsson E, Prince JA, Pedersen NL. Sortilin receptor 1 predicts longitudinal cognitive change. Neurobiol Aging. 2013 Jun;34(6):1710.e11-8.

Rolstad S, Berg AI, Bjerke M, Johansson B, Zetterberg H, Wallin A. Cerebrospinal fluid biomarkers mirror rate of cognitive decline. J Alzheimer’s Dis. 2013 Jan 1;34(4):949-56.

Sjöberg L, Östling S, Waern M, Falk H, Skoog I. Secular changes in the relation between depression and social factors. A study of two birth cohorts of Swedish septuagenarians followed for 5 years. J Affect Disord. 2013 Sep 5;150(2):245-52.

Soveri A, Tallus J, Laine M, Nyberg L, Bäckman L, Hugdahl K, Tuomainen J, Westerhausen R & Hämäläinen H. Modulation of auditory attention by training. Experimental Psychology, 2013;60:44-52.

Wang HX, Jin Y, Hendrie HC, Liang C, Yang L, Cheng Y, Unverzagt FW, Ma F, Hall KS, Murrell JR, Li P, Bian J, Pei JJ, Gao S. Late life leisure activities and risk of cognitive decline. J Gerontol A Biol Sci Med Sci. 2013 Feb;68(2):205-13.

Wiberg P, Waern M, Billstedt E, Östling S, Skoog I. Secular trends in the prevalence of dementia and depression in Swedish septugenarians 1976- 2006. Psychol Med. 2013 Mar 12:1-8.

Xu WL, Caracciolo B, Wang HX, Santoni G, Winblad B, Fratiglioni L. Accelerated progression from mild cognitive impairment to dementia among APOE ε4ε4 carriers. J Alzheimer’s Dis. 2013;33(2):507-15.

Zhang H, Xu W,  Dahl A, Xu Z, Wang HX, Qi X. Relation of socioeconomic status to impaired fasting glucose and type 2 diabetes: findings based on a large population-based cross-sectional study in Tianjin, China. Diabet Med. 2013 Feb 8.

Zhi X, Joas E, Waern M, Östling S, Börjesson-Hanson A, Skoog I.  Prevalence of cardiovascular disorders and risk factors in two 75-year-olds birth cohorts examined in 1976-77 and 2005-06. Aging Clin Exp Res. 2013;25:377-83

Zimmermann-Viehoff F, Wang HX, Kirkeeid R, Schneiderma N, Erdur L, Dete H-C, K. Women’s Exhaustion and Coronary Artery Atherosclerosis Progression. The Stockholm Female Coronary Angiography Study. Psychosom Med. 2013 Jun;75(5):478-85.

 

Vård och omsorgsforskning

(vård, rehabilitering, teknologi, primärvård, hälsoekonomi)

Kvitting AS, Wimo A, Johansson MM, Marcusson J. A quick test of cognitive speed (AQT): usefulness in dementia evaluations in primary care. Scand J Prim Health Care. 2013 Mar;31(1):13-9.

Lindgren H, Nilsson I. Towards User-Authored Agent Dialogues for Assessment in Personalised Ambient Assisted Living. Int. J. of Web Engineering and Technology, 2013;8(2):154-176.

Lindgren H. Sociotechnical Systems as Innovation Systems in the Medical and Health Domain. Stud Health Technol Inform 2013;194:35-40.

Orrung Wallin A, Edberg AK, Beck I, & Jakobsson U. Psychometric properties concerning four instruments measuring job satisfaction, strain and stress of conscience in a residential care context. Archives of Gerontology and Geriatrics, 2013;57(2): 162-171.

Orrung Wallin, A., Jakobsson, U. & Edberg, A-K. (2013) Job strain and stress of conscience among nurse assistants working in residential care. J Nursing Management, E-pub ahead of print.

Sköldunger AWimo AJohnell K. Net costs of dementia in Sweden – an incidence based 10 year simulation study. Curr Alzheimer Res. 2013 Feb;10(2):207-16.

Surie D, Lindgren H, Qureshi A. Kitchen AS-A-PAL: Exploring Smart Objects as Containers, Surfaces and Actuators. In: Ambient Intelligence-Software and Applications, pp. 171–178. Springer, 2013.

Tallberg I-M, Stormoen S, Almkvist O, Eriksdotter M, Sundström E. Investigating medical decision-making capacity in patients with cognitive impairment using a protocol based on linguistic features. Scand J Psychol. 2013;54:386-92, 2013.

 

 

 

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