SV EN

2012

Grundforskning

(experimentell forskning, genetik, djurmodeller)

Anvret A, Ran C, Westerlund M, Gellhaar S, Lindqvist E, Pernold K, Lundströmer K, Duester G, Felder MR, Olson L, Galter D and Belin AC. Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson’s disease. Behavioral Brain Research. 2012 Feb 1;227(1):252-7.

Anvret A, Ran C, Westerlund M, Galter D, Sydow O, Willows T, Olson L, Belin AC. Genetic Screening of Mitochondrial Rho GTPases, MIRO1 and MIRO2, in Parkinson’s disease. Open Neurol J. 2012;6:1-5. 

Belin AC, Ran C, Anvret A, Paddock S, Westerlund M, Håkansson A, Nissbrandt H, Söderkvist P, Dizdar N, Ahmadi A, Anvret M, Willows T, Sydow O, Galter D. Association of a protective paraoxonase 1 (PON1) polymorphism in Parkinson’s disease. Neurosci Lett. 2012 Jul 26;522(1):30-5.

Borgegård T, Gustavsson S, Nilsson C, Parpal S, Klintenberg R, Berg AL, Rosqvist S, Serneels L, Svensson S, Olsson F, Jin S, Yan H, Wanngren J, Jureus A, Ridderstad-Wollberg A, Wollberg P, Stockling K, Karlström H, Malmberg A, Lund J, Arvidsson PI, De Strooper B, Lendahl U, Lundkvist. J.Alzheimer’s disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy. J Neurosci. 2012 Nov 28;32(48):17297-305.

Carmine Belin A, Ran C, Anvret A, Paddock S, Westerlund M,Håkansson A, Nissbrandt H, Söderkvist P, Dizdar N, Ahmad Ahmadi A, Anvret M, Willows T,Sydow O, Galter D.Association of a protective paraoxonase 1 (PON1) polymorphism in Parkinson’s disease. Neuroscience Lett, 522, 30-35, 2012.

Corcia P, Ingre C, Blasco H, Press R, Praline J, Antar C, Veyrat C, GuettardYO, Camu W, Andersen PM, Andres C, Vourc’h P. Homozygous SMN2 deletion is a protective factor in the Swedish ALS population. Eur J Hum Genet 2012;20:588-91.

Daher JP, Pletnikova O, Biskup S, Musso A, Gellhaar S, Galter D, Troncoso JC, Lee MK, Dawson TM, Dawson VL, Moore DJ. Neurodegenerative phenotypes in an A53T a-synuclein transgenic mouse model are independet of LRRK2. H um Mol Genet. 2012 Jun 1; 21(11):2420-31.

Diekstra FP, van Vught PWJ, van Rheenen W, Koppers M, Pasterkamp RJ, van Es MA, Schelhaas HJ, de Visser M, Robberecht W, Andersen PM, van den Berg LH, Veldink JH. UNC13A is a modifier of survival in amyotrophic lateral sclerosis. Neurobiol Aging 2012;33.

Diekstra FP, Saris CGJ, van Rheenen W, Franke L, Jansen RC, van Es MA, van Vught PWJ, Blauw HM, Groen EJN, Horvath S, Karol Estrada K, Rivadeneira F, Hofman A, Uitterlinden AG, Robberecht W, Andersen PM, Melki J, Meininger V, Hardiman O, Landers JE, Brown, Jr. RH, Shatunov A, Shaw CE, Leigh PN, Al-Chalabi A, Ophoff RA, van den Berg LH, Veldink JH. Mapping of Gene Expression Reveals CYP27A1 as a Susceptibility Gene for Sporadic ALS. PloS ONE 2012;7:e35333.

Fourgeux C, Dugas B, Richard F, Björkhem I, Acar N, Bron AM, Korobelnik JF, Levezei N, Zerbib J, Puche N, Creuzot-Garcher CP, Bretillon L Single nucleotide polymorphism in the cholesterol 24S-hydroxylase (CYP46A1) gene and its association with CFH and LOC387715 gene polymorphisms in age-related macular degeneration. Invest Ophtalmol Vis Sci. 53 (2012) 7026-7033.

Gil-Bea F, Akterin S, Persson T, Mateos L, Sandebring A, Avila-Cariño J, Gutierrez-Rodriguez A, Sundström E, Holmgren A, Winblad B, Cedazo-Minguez A.Thioredoxin-80 is a product of alpha-secretase cleavage that inhibits amyloid-beta aggregation and is decreased in Alzheimer’s disease brain. EMBO Mol Med. 2012 Oct;4(10):1097-111.

Gispert S, Kurz A, Waibel S, Bauer P, Liepelt I; Geisen C, Gitler AD, Becker T, Weber M, Berg D, Andersen PM, Krüger R, Riess O, Ludolph AC, Auburger G. The modulation of Amyotrophic Lateral Sclerosis risk by Ataxin-2 intermediate polyglutamine expansions is a specific effect. Neurobiol Dis 2012;45:356-361.

Hedskog L, Brohede J, Wiehager B, Pinho CM, Revathikumar P, Lilius L, Glaser E, Graff C, Karlström H, Ankarcrona M. Biochemical Studies of Poly-T Variants in the Alzheimer’s Disease Associated TOMM40 Gene. J Alzheimers Dis. 2012 May 16.

Hjorth E, Freund-Levi Y. Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid. Curr Opin Clin Nutr Metab Care 2012;15:134-143.

Ibáñez C, Simó C, Martín-Álvarez PJ, Kivipelto M, Winblad B, Cedazo-Mínguez A, Cifuentes A. Toward a predictive model of Alzheimer’s disease progression using capillary electrophoresis-mass spectrometry metabolomics. Anal Chem. 2012 Oct 16;84(20):8532-40.

Kacem I, Funalot B, Torny F, Lautrette G, Andersen PM, Couratier P. Early-onset parkinsonism associated with an intronic SOD1 mutation. ALS 2012;13:315-317.

Katz JS, Katzberg HD, Woolley SC, Marklund SL, Andersen PM. Fronto-temporal dementia with Aphasia and later Amyotrophic Lateral Sclerosis in a Patient with the I113T SOD1 Gene Mutation. ALS 2012;13:567-9.

Lee SM, Sterky FH, Mourier A, Terzioglu M, Paganelli A, Cullheim S, Olson L, Larsson NG. Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons. Hum Mol Genet, 21, 4827-4835, 2012.

Maioli S, Puerta E, Merino-Serrais P, Fusari L, Gil-Bea F, Rimondini R, Cedazo-Minguez A. Combination of apolipoprotein e4 and high carbohydrate diet reduces hippocampal BDNF and arc levels and impairs memory in young mice. J Alzheimers Dis. 2012 Jan 1;32(2):341-55.

Miralbell J, Spulber G, Hooshmand B, Besga A, Mataró M, Cedazo-Minguez A, Kivipelto M, Wahlund LO. Grey matter and cognitive patterns in cognitive impaired subjects using CSF biomarker cut-offs. J Alzheimers Dis. 2012;29(4):741-9.

Ran C, Westerlund M, Anvret A, Willows T, Sydow O, Galter D, Belin AC. Genetic studies of the protein kinase AKT1 in Parkinson’s disease. Neurosci Lett. 2011 Aug 21;501(1):41-4.

Sarlus H, Olgart Höglund C, Karshikoff B, Wang X, Lekander M, Schultzberg M, Oprica M. Allergy influences the inflammatory status of the brain and enhances tau phosphorylation. J Cell Mol Med 2012 Feb 22.

Sharma M, Ioannidis JP, Aasly JO, Annesi G, Brice A, Van Broeckhoven C, Bertram L, Bozi M, Crosiers D, Clarke C, Facheris M, Farrer M, Garraux G, Gispert S, Auburger G, Vilariño-Güell C, Hadjigeorgiou GM, Hicks AA, Hattori N, Jeon B, Lesage S, Lill CM, Lin JJ, Lynch T, Lichtner P, Lang AE, Mok V, Jasinska-Myga B, Mellick GD, Morrison KE, Opala G, Pramstaller PP, Pichler I, Park SS, Quattrone A, Rogaeva E, Ross OA, Stefanis L, Stockton JD, Satake W, Silburn PA, Theuns J, Tan EK, Toda T, Tomiyama H, Uitti RJ, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Yueh KC, Zhao Y, Gasser T, Maraganore D, Krüger R; *GEO-PD Consortium. Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology. 2012 Aug 14;79(7):659-67 *Global Site Principal investigator of GEO-PD in Sweden.

Sterky FH, Hoffman AF, Milenkovic D, Bao B, Paganelli A, Edgar D, Wibom R, Lupica CR, Olson L, Larsson NG. Altered dopamine metabolism and increased vulnerability to MPTP in mice with partial deficiency of mitochondrial complex I in dopamine neurons. Hum Mol Genet 2012;21:1078-1089.

Smith BN, Newhouse S, Vance C, Lee Y, Weale ME, Topp S, Millar J, Johnson L, Troakes C, Hortobagyi T, Al-Sarraj S, Rogelj B, Powell J, Lupton M, Lovestone S, Sapp P, Nestor PS, Schelhaas, Silani V, Gelera C, Van den Berg L, Veldink J, van Damme P, Robberecht W, de Jong V, Shaw PJ, Kirby J, Paul H, Morrison KE, Bass, Andersen PM, Landers J, Brown RH, Al-Chalabi A, Shaw CE. The C9ORF72 expansion mutation is derived from a single founder in European ALS/FTD patients and is highly unstable. Eur J Hum Genet, Epub June 13, 2012.

Synofzik M, Rochi D, Keskin I, Basak AN, Wilhelm C, Gobbi C, Birve A, Biskup S, Zecca C, Fernandez-Santiago R, Kaugesaar T, Schöls L, Marklund SL, Andersen PM. Mutant Superoxide Dismutase-1 Indistinguishable from Wild Type Causes ALS. Hum Mol Genet 2012;21:3568-3574.

van Hoecke A, Schoonaert L, Lemmens R, Timmers M, Staats KA, Laird AS, Peeters E, Philips T, Goris A, Dubois B, Andersen PM, Al-Chalabi A, Thijs V, Turnley AM, van Vught PW, Veldink JH, Van Den Bosch L, Gonzalez-Perez P, Van Damme P, Brown Jr RH, van den Berg LH, Robberecht W. EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans. Nat Med 2012;18:1418-1422.

Wanngren J, Ottervald J, Parpal S, Portelius E, Strömberg K, Borgegård T, Klintenberg R, Juréus A, Blomqvist J, Blennow K, Zetterberg H, Lundkvist J, Rosqvist S, Karlström H.  Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.  J Biol Chem. 2012 Jul 31.

Wuolikainen A, Moritz T, Marklund SL, Andersen PM, Antti H. ALS patients with mutations in the SOD1 gene have an unique metabolomic profile in the cerebrospinal fluid compared with ALS patients without mutations. Mol Genet Metabol 2012;105:472-8.

Zhang YJ, Granholm AC, Shan L, Diaz O, Malik N, Olson L, Huh K, Hoffer BJ, Lupica CR, Hoffman AF, Bäckman CM. Lack of PTEN enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice. Brain 2012;135:2736-2749.

Zheng L, Cedazo-Minguez A, Hallbeck M, Jerhammar F, Marcusson J, Terman A. Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system. Transl Neurodegener. 2012 Sep 26;1(1):19.

 

Klinisk forskning

(diagnostik, behandling, kliniska prövningar, epidemiologi, neuropsykologi)

Andersson M, Guo X, Börjesson-Hanson A, Liebetrau M, Östling S, Skoog I. A population based study on dementia and stroke in 97-year-olds. Age Ageing. 2012 Jul;41(4):529-33.

Andel R, Crowe M, Hahn EA, Mortimer JA, Pedersen NL, Fratiglioni L, Johansson B, Gatz M.  Work-related stress may increase the risk of vascular dementia. J Am Geriatr Soc. 2112;60(1):60-67.

Bao et al. Different amyloid oligomer assemblies in Alzheimer brains correlate with age of diease onset and impaired cholinergic activit. Neurobiol Aging 2012;33.

Brehmer Y, Westerberg H & Bäckman L. Working-memory training in younger and older adults: Training gains, transfer, and maintenance. Frontiers in Human Neuroscience, 2012;(6):63.

Brown CL, Gibbons LE, Kennison RF, Robitaille A, Lindwall M, Mitchell MB, Shirk SD, Atri A, Cimino CR, Benitez A, Macdonald SW, Zelinski EM, Willis SL, Schaie KW, Johansson B, Dixon RA, Mungas DM, Hofer SM, Piccinin AM. Social activity and cognitive functioning over time: a coordinated analysis of four longitudinal studies. J Aging Res. 2012; 287438.

Burzynska AZ, Nagel IE, Preuschhoff C, Gluth S, Bäckman L, Li S-C, Lindenberger U & Heekeren HR. (2012). Cortical thickness is linked to executive functioning in adulthood and aging. Human Brain Mapping, 33, 1607-1620.

Caracciolo B, Gatz M, Xu W, Pedersen N, Fratiglioni L. Differential Distribution of Subjective and Objective Cognitive Impairment in the Population: A Nation-Wide Twin-Study. J Alzheimers Dis. 2012;29(2):393-403.

Cavallin L, Bronge L, Zhang Y, Oksengård AR, Wahlund LO, Fratiglioni L, Axelsson R. Comparison between visual assessment of MTA and hippocampal volumes in an elderly, non-demented population.  Acta Radiol. 2012 Jun 1;53(5):573-9.

Clerici F, Caracciolo B, Cova I, Fusari Imperatori S, Maggiore L, Galimberti D, Scarpini E, Mariani C, Fratiglioni L. Does vascular burden contribute to the progression of mild cognitive impairment to dementia? Dement Geriatr Cogn Disord. 2012;34(3-4):235-43. 

Carter S et al. Evidence for astrocytosis in prodromal Alzheimer’s disease provided by 11C-Deuterium-L-Deprenyl – A multi-tracer PET paradigm combining 11C-PIB and 18F-FDG. J Nucl Med, 2012;53:37-46.

Ekman, U, Eriksson J, Forsgren L, Mo S J, Riklund K, & Nyberg L. Functional brain activity and presynaptic dopamine uptake in patients with Parkinson’s disease and mild cognitive impairment: a cross-sectional study. Lancet Neurology, 2012;11(8):679–687.

Eriksdotter-Jönhagen M, Linderoth B, Lindb G,  Aladellie L, Almkvist O, Andreasen N, Blennow K, Bogdanovic N, Jelic V, Kadir A, Nordberg A, Sundström E, Wahlund LO, Wall A, Wiberg M, Winblad B, Seiger Å, Almqvist P, Wahlberg. Encapsulated cell biodelivery of NGF to the basal forebrain in patients with Alzheimer´s disease. Dem Ger Cogn Disord.  2012;33:18-28.

Eriksdotter-Jönhagen M, Linderoth B, Lind G, Eyjolfsdottir H, Seiger Å, Almqvist P, Wahlberg L. Intracerebral  tillförsel av tillväxtfaktorn NGF med inkapslade celler hos patienter med Alzheimers sjukdom. Neurologi 1: 25-30, 2012.

Forsberg A, Engler H, Blomquist G et al. The use of PIB PET as a dual pathological and functional biomarker in AD. Biochemica et Biophysica Acta 2012:1822: 380-385.

Gustafson DR, Bäckman K, Joas E, Waern M, Östling S, Guo X, Skoog I. A 37-years of body mass index and dementia. Observations from the Prospective Population Study of Women in Gothenburg, Sweden. J Alzheimers Dis 2012 Jan;28(1):163-71.

Gustafson D, Bäckman K, Lissner L, Carlsson L,  Waern M, Östling S, Guo X, Bengtsson C, Skoog I. Leptin and dementia over 32 years – the Prospective Population Study of Women. Alzheimer’s & Dement. 2012 Jul;8(4):272-7.

Hansson O, Stomrud E, Vanmechelen E, Östling S, Gustafson D, Zetterberg H, Blennow K, Skoog I. Evaluation of plasma Aβ as predictor of Alzheimer’s disease in older individuals without dementia: a population-based study. J Alzheimers Dis. 2012 Jan;28(1):231-8.

Hjelm C, Dahl A, Broström A, Mårtensson J, Johansson B, Strömberg A. The influence of heart failure on longitudinal changes in cognition among individuals 80 years of age and older. J Clin Nurs2012;21(7-8):994-1003.

Jacobs AH, Taviatian B and the INMIND consortium. Noninvasive molecular imaging of neuroinflammation. J Cereb Blood FLow Metab 2012: 32:  1393-1415.

Joas E, Bäckman K, Gustafson D, Östling S, Waern M, Guo X, Skoog I. Trajectories of blood pressure from mid- to late-life in relation to dementia in women followed for 37 years. Hypertension 2012 Apr;59(4):796-801.

Johansson L Skoog I, Gustafson D, Olesen PJ, Waern Bengtsson C, Björkelund C, Pantoni L, Simoni M, Lissner L, Guo X, Midlife psychological distress associated with late-life brain atrophy and white matter lesions: a 32-year population study of women. Psychosom Med. 2012 Feb-Mar;74(2):120-5.

Jokinen H, Lipsanen J, Schmidt R, Fazekas F, Gouw AA, van der Flier WM, Barkhof F, Madureira S, Verdelho A, Ferro JM, Wallin A, Pantoni L, Inzitari D, Erkinjuntti T; LADIS Study Group. Brain atrophy accelerates cognitive decline in cerebral small vessel disease: the LADIS study. Neurology 2012 May 29;78(22):1785-92.

Jonsson M, Skoog I, Marlow T, Mellqvist M, Waern M. Anxiety symptoms and suicidal feelings in a population sample of non-demented 70-year-olds. Int Psychogeriatr. 2012;24:1865-71.

Jonsson Laukka E, MacDonald S W S, Fratiglioni L & Bäckman L. Preclinical cognitive trajectories differ for Alzheimer’s disease and vascular dementia. J Int Neuropsychol Society, 2012;18: 1-9.

Kadir A, Almkvist O, Forsberg A et al. Dynamic changes in PET amyloid and FGD imaging at different stages of Alzheimer´s disease. Neurobiology of Aging 2012: 33: 198e-198e14.

Lak VW, Guo X, Skoog I. Secular trends in lung function and its relation to survival in Swedish 75-year olds 1976-2006. Age Ageing. 2012;41:735-40.

Landgren S, von Otter M, Seibt Palmér M, Zetterström C, Nilsson S, Skoog I, Gustafson DR, Minthon L, Wallin A, Andreasen N, Bogdanovic N, Marcusson J, Blennow K, Zetterberg H, Kettunen P. A novel ARC gene polymorphism is associated with reduced risk of Alzheimer’s disease. J Neural Transm. 2012 Jul;119(7):833-42.

Laukka EJ, MacDonald SWS, Fratiglioni L, Bäckman L Preclinical cognitive trajectories differ for Alzheimer’s disease and vascular dementia. JINS 2012;18:1-9.

Lindberg O, Walterfang M, Looi JCL, Malykhin N, Ostberg P, Zandbelt BB, Oberg J, Zhang Y, Wahlund L-O. Hippocampal shape analysis in Alzheimer´s disease and frontotemporal lobar degeneration subtypes. J Alzheimers Dis. 2012 Jan 1;30(2):355-65.

Lindwall M, Cimino CR, Gibbons LE, Mitchell MB, Benitez A, Brown CL, Kennison RF, Shirk SD, Atri A, Robitaille A, Macdonald SW, Zelinski EM, Willis SL, Schaie KW, Johansson B, Praetorius M, Dixon RA, Mungas DM, Hofer SM, Piccinin AM. Dynamic associations of change in physical activity and change in cognitive function: coordinated analyses of four longitudinal studies. J Aging Res. 2012;493598.

Lövdén M, Schaefer S, Noack H, Bodammer N, Kühn S, Heinze H-J, Düzel E, Bäckman L & Lindenberger U. Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood. Neurobiology and Aging, 2012;33:620.

MacDonald S W S, Karlsson S, Rieckmann A & Bäckman L. Age-related increases in behavioral variability: Relations to losses of dopamine D1 receptors. Journal of Neuroscience, 2012;32: 8186-8191.

Mangialasche F, Kivipelto M, Solomon A, Fratiglioni L. Dementia prevention: current epidemiological evidence and future perspective. Alzheimers Res Ther. 2012 Feb 13;4(1):6

Mitchell MB, Cimino CR, Benitez A, Brown CL, Gibbons LE, Kennison RF, Shirk SD, Atri A, Robitaille A, Macdonald SW, Lindwall M, Zelinski EM, Willis SL, Schaie KW, Johansson B, Dixon RA, Mungas DM, Hofer SM, Piccinin AM. Cognitively Stimulating Activities: Effects on Cognition across Four Studies with up to 21 Years of Longitudinal Data. J Aging Res. 2012;461592. Epub 2012 Sep 13.

Nilsson J, Ostling S, Waern M, Karlsson B, Sigström R, Guo X, Skoog I.. The 1-month prevalence of Generalized Anxiety Disorder according to DSM-IV, DSM-V and ICD-10 among non-demented 75-year-olds in Gothenburg, Sweden. Am J Geriatr Psychiatry. 2012;20:963-72.

Nordberg A et al.  European multi-center PET study of fibrillar amyloid in Alzheimer´s disease. Eur J Nucl Med Mol Imaging DOI 10.1007/s00259-012-2237-2.

Nyberg L, Lövdén M, Riklund K, Lindenberger U & Bäckman L. Memory aging and brain maintenance. Trends in Cognitive Sciences, 2012;16:292-305.

Paillard-Borg S, Fratiglioni L, Xu W, Winblad B, Wang HX. An active lifestyle postpones dementia onset by more than one year in very old adults.  J Alzheimer’s Dis. 2012;31(4):835-42.

Qiu C, Zhang Y, Bronge L, Herlitz A, Aspelin P, Bäckman L, Fratiglioni L, Wahlund LO. Medial temporal lobe is vulnerable to vascular risk factors in men: a population-based study. Eur J Neurol 2012 Jan 17.

Religa D, Spångberg K, Wimo A, Edlund A-K, Winblad B, Eriksdotter-Jönhagen M. Dementia diagnosis differs in men and women and depends on age and dementia severity. Data from SveDem, the Swedish Dementia Quality Registry. Ger Cogn Disord 2012;33:90-95.

Richard E, Andrieu S, Solomon A, Mangialasche F, Ahtiluoto S, Moll van Charante EP, Coley N, Fratiglioni L, Neely AS, Vellas B, van Gool WA, Kivipelto M.  Methodological challenges in designing dementia prevention trials – the European Dementia Prevention Initiative (EDPI). J Neurol Sci. 2012 Nov 15;322(1-2):64-70.

Rieckmann A, Karlsson S, Fischer H & Bäckman L. Increased bilateral frontal connectivity in younger adults under the influence of a dopamine D1 receptor antagonist. J Neuroscience 2012;32: 17067-17072.

Rizzuto D, Orsini N, Qiu C, Wang HX, Fratiglioni L. Lifestyle, social factors, and survival after age 75: population based study. BMJ. 2012 Aug 29;345:e5568

Robitaille A, Muniz G, Piccinin AM, Johansson B, Hofer SM. Multivariate Longitudinal Modeling of Cognitive Aging: Associations Among Change and Variation in Processing Speed and Visuospatial Ability. GeroPsych (Bern). 2012;25(1):15-24.

Rolstad S, Berg AI, Zetterberg H, Johansson B, Wallin A. All cognitive systems but speed and visuospatial functions reduce the effect of CSF pathology on other systems. Curr Alzheimer Res. 2012 Nov;9(9):1043-9.

Rydwik E, Welmer AK, Kåreholt I, Angleman S, Fratiglioni L, Wang HX. Adherence to physical exercise recommendations in people over 65–The SNAC-Kungsholmen study.  Eur J Public Health. 2012 Oct 31.

Sehlin D, Englund H, Simu B, Karlsson M, Ingelsson M, Nikolajeff F, Lannfelt L, Pettersson FE. Large aggregates are the major soluble Aβ species in AD brain fractionated with density gradient ultracentrifugation. PLoS One. 2012;7(2):e32014.

Schöll M et al. Low PIB PET retention in presence of pathological CSF biomarkers in Arctic APP mutation carriers. Neurology 2012;79:229-236.

Skoog I, Olesen PJ, Blennow K, Palmertz B, Johnson SC, Bigler ED. Head size may modify the impact of white matter lesions on dementia . Neurobiol Aging. 2012 Jul;33(7):1186-93.

Thorvaldsson V, Skoog I, Hofer SM, Börjesson-Hansson A, Östling S, Sacuiu S, Johansson B. Non-linear blood pressure effects on cognition in old age: Separating between-person and within-person associations. Psychol Aging. 2012 Jun;27(2):375-83.

Torisson G, Minthon L, Stavenow L, Londos E. Cognitive impairment is undetected in medical inpatients: a study of mortality and recognition amongst healthcare professionals. BMC Geriatr. 2012;12:47.

Wang H-X, Gustafson DR, Kivipelto M, Pedersen NL, Skoog I, Windblad B, Fratiglioni L. Education halves the risk of dementia due to apolipoprotein epsilon 4 allele: A collaborative study from the Swedish Brain Power initiative. Neurobiol Aging. 2012 May;33(5):1007.e1-7.

Wahlberg LU, Lind G, Almqvist PM, Kusk P, Tornøe J, Juliusson B, Söderman M, Selldén E, Seiger, Å, Eriksdotter-Jönhagen M. Linderoth, B,.Targeted therapy of NGF in Alzheimer’s disease with EC Biodelivery™ – A technology platform for restorative neurosurgery, J Neurosurg. 2012;117:340- 347.

Welmer AK, Kåreholt I, Angleman S, Rydwik E, Fratiglioni L. Can chronic multimorbidity explain the age-related differences in strength, speed and balance in older adults? Aging Clin Exp Res. 2012 Oct;24(5):480-9.

Wenger E, Schaefer S, Noack H, Kühn S, Mårtensson J, Heinze H-J, Düzel E, Bäckman L, Lindenberger U & Lövdén M. Cortical thickness changes following spatial navigation training in adulthood and aging. Neuroimage, 2012;59: 3389-339.

Villemagne V, Klunk WE, Mathis CA et L: Aß imaging: feasible, pertinent, and vital to progress in Alzheimer´s disease. Eur J Jucl Med Mol Imaging 2012: 39:  209-2

Xu W, Xu Z, Jia J, Xie Y, Wang HX, Qi X. Detection of Prediabetes and Undiagnosed Type 2 Diabetes: A Large Population-based Study. Can J Diabetes. 2012;36(3):108-13.

 

Vård och omsorgsforskning

(vård, rehabilitering, teknologi, primärvård, hälsoekonomi)

Bergland, Å, Kirkevold M, Edvardsson D. Psychometric properties of the Norwegian Person-centered Climate Questionnaire from a nursing home context. Scand J Caring Sciences. DOI: 10.1111/j.1471-6712.2012.00979.

Boman I-L, Rosenberg L, Lundberg S & Nygård L. A first step in designing a videophone for people with dementia: identification of the users’ potentials and the requirements on the communication technology. Disability and Rehabilitation: Assistive Technology, 2012;7(5):356-363.

Borell L, Nygård L, Asaba E, Gustavsson A & Hemmingsson H. Qualitative Approaches in Occupational Therapy Research. Scandinavian J Occupational Therapy, 2012;9,(oct): 521-529.

Edvardsson D, Sandman PO & Rasmussen B. Forecasting the ward climate: A study from a dementia care unit. J Clin Nursing 2012 21, 1136-1144.

Lindgren H, Winnberg PJ, Yan C. Collaborative Development of Knowledge-Based Support Systems: A Case Study. Stud Health Technol Inform 2012;180:1111-1113.

Lindholm C, Gustavsson A, Jönsson L, Wimo A. Costs explained by function rather than diagnosis—results from the SNAC Nordanstig elderly cohort in Sweden. Int J Geriatr Psychiatry. 2012;jul 11.

Malinowsky C, Almkvist O, Nygård L & Kottorp A. Individual variability and environmental characteristics influence older adults’ abilities to manage everyday technology. International Psychogeriatrics, 2012; 24:484-495.

Nieves JC, Surie D, Lindgren H. Modeling Actions Based on a Situative Space Model for Recognizing Human Activities. In: A. Ramsay and G. Agre (Eds.): AIMSA 2012, LNAI 7557, pp. 266-275.

Nygård L, Pantzar M, Uppgard B & Kottorp A. Detection of disability in older adults with MCI or Alzheimer’s disease through assessment of perceived difficulty in using everyday technology. Aging and Mental Health, 2012;16(3-4):361-371.

Orrung Wallin, A., Jakobsson, U., Edberg, A-K.  Job-satisfaction and associated variables among nurse assistants working in residential care. International Psychogeriatrics, 2012;24(12): 1904-1918.

Pellfolk T, Lövheim H, Sandman PO, Gustafsson Y, Karlsson S. Physical restraint use in geriatric care in Sweden between 2000 and 2007. Int Psychogeriatr 201224:7,1144–1152.

Rokstad AMM, Engedal K, Edvardsson D, Selbæk G. Validity and reliability of the Norwegian version of the Person-centred Care Assessment Tool (P-CAT). Int J of Nursing Practice 2012; 18, 99-105.

Sandman PO, Edvardsson D. Existential outcomes of person-centred care – how can such be measured, achieved, implemented and disseminated. The Gerontologist 2012;52 (s1), 451.

Sjögren K, Petersson L, Sandman P, Edvardsson D. Everyday activities are associated with higher resident quality of life. The Gerontologist 52 (s1), 451.

Sjögren K, Lindqvist M, Zingmark K, Sandman PO, Edvardsson D. Person-Centredness and its association with resident well-being in dementia care units. Journal of Advanced Nursing 2012.

Sjögren K, Sandman PO, Zingmark K, Edvardsson D. Psychometric evaluation of the Swedish version Person-centred Care Assessment Tool (P-CAT). Int Psychogeriatrics 2012 24, 406-415.

Sköldunger A, Wimo A, Johnell K. Net costs of dementia in Sweden – An Incidence Based 10 Year Simulation Study. Int J Geriatr Psychiatry. 2012 Feb 1.

Sköldunger AJohnell KWinblad BWimo A. Mortality and treatment costs have a great impact on the cost-effectiveness of disease modifying treatment in Alzheimer’s disease–a simulation study. Int J Geriatr Psychiatry. 2012 Nov 27(11):1112-7.

Wimo A, Gaudig M, Schäuble B, Jedenius E. The economic impact of galantamine vs placebo: An analysis based on functional capacity in a Swedish cohort study. J Med Econ. 2012 Apr 23.

 

© 2010 Swedish Brain Power