SV EN

2011

Grundforskning

(experimentell forskning, genetik, djurmodeller)

Carew JD, Nair G, Gronka S, Hu X, Andersen PM, Benatar M. Presymptomatic spinal cord neurometabolomic findings in SOD1+ people at risk of familial ALS. Neurology 2011;77:1370-1375.

Couthis J, Hart MP, Shorter J, Dejesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Solski JA, Williams KL, Mojsilovic-Petrovic J, Ingre C, Boylan K, Graff-Radford NR, Dickson DW, Clay-Falcone D, Elman L, McCluskey L, Greene R, Kalb RG, Lee VM, Trojanowski JQ, Ludolph A, Robberecht W, Andersen PM, Nicholson GA, Blair IP, King OD, Bonini NM, Van Deerlin V, Rademakers R, Mourelatos Z, Gitler AD. Feature article: A yeast functional screen predicts new candidate ALS disease genes. Proc Natl Acad Sci U S A 2011;108:20881-20890.

Lee T, Li YR, Ingre C, Weber M, Grehl T, Gredal O, de Carvalho M, Meyer T, Tysnes O-B, Auburger G, Gispert S, Andersen PM, Gitler AD. Ataxin-2 intermediate-length polyglutamine expansions in European ALS patients. Hum Mol Genet 2011;9:1697-1700.

Pamrén A, Wanngren J, Tjernberg LO, Winblad B, Bhat R, Näslund J, Karlström H. Mutations in nicastrin protein differentially affect amyloid beta-peptide production a Notch protein processing. J Biol Chem. 2011 Sep 9;286(36):31153-8.

Ross JM. Visualization of mitochondrial respiratory function using cytochrome oxidase / succinate dehydrogenase (COX/SDH) double-labeling histochemistry. Journal of Visualized Experiments (57), e3266, DOI: 10.3791/3266 (2011). PMID:22143245

Ross OA, Soto-Ortolaza AI, Heckman MG, Aasly JO, Abahuni N, Annesi G, Bacon JA, Bardien S, Bozi M, Brice A, Brighina L, Van Broeckhoven C, Carr J, Chartier-Harlin MC, Dardiotis E, Dickson DW, Diehl NN, Elbaz A, Ferrarese C, Ferraris A, Fiske B, Gibson JM, Gibson R, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Jeon BS, Kim YJ, Klein C, Kruger R, Kyratzi E, Lesage S, Lin CH, Lynch T, Maraganore DM, Mellick GD, Mutez E, Nilsson C, Opala G, Park SS, Puschmann A, Quattrone A, Sharma M, Silburn PA, Sohn YH, Stefanis L, Tadic V, Theuns J, Tomiyama H, Uitti RJ, Valente EMvan de Loo S, Vassilatis DK, Vilariño-Güell C, White LR, Wirdefeldt K, Wszolek ZK, Wu RM, Farrer MJ; Genetic Epidemiology Of Parkinson’s Disease (GEO-PD) Consortium*. Association of LRRK2 exonic variants with susceptibility to Parkinson’s disease: a case-control study. Lancet Neurol. 2011 Oct;10(10):898-908. * Global Site Principal investigator of GEO-PD in Sweden.

Spulber S, Bartfai T, Winblad B, Schultzberg M. Morphological and behavioural changes induced by transgenic overexpression of IL-1ra in the brain. J Neurosci Res 2011;89:142-52.

van Es MA, Schelhaas HJ, van Vught PWJ, Ticozzi N Andersen PM, Groen EJN, Schulte C, Blauw HM, Koppers M, Diekstra FP, Fumoto K, LeClerc AL, Keagle P, Bloem BR, Scheffer H, van Nuenen BFL, van Blitterswijk M, van Rheenen W, Wills A-M, Lowe PP, Hu G, Yu W, Kishikawa H, Wu D, Folkerth RD, Mariani C, Goldwurm S, Pezolli G,van DammeP, Lemmens R, Ingre C, Birve A, Fernández-Santiago R, Waibel S, Klein C, Weber M, van der Kooi AJ, de Visser M, Verbaan D, van Hilten BJ, Heutink P, Hennekam EAM, Cuppen E, Berg D, Brown Jr RH, Silani V, Gasser T, Ludolph AC, Robberecht W, Ophoff RA, Veldink JH, Pasterkamp RJ, de Bakker PIW, Landers JE, van de Warrenburg BP, van den Berg LH. Angiogenin variants in Parkinson’s Disease and amyotrophic lateral sclerosis. Ann Neurol 2011;70:964-973.

Weber M, Neuwirth C, Schweikert K, Czaplinski A, Jung HH, Birve A, Marklund SL, Andersen PM.  ALS patients with SOD1 mutations in Switzerland show very diverse phenotypes and extreme long survival. J Neurol Neurosurg Psychiatry 2011.

 

 Klinisk forskning

(diagnostik, behandling, kliniska prövningar, epidemiologi, neuropsykologi)

Andel R, Crowe M, Hahn EA, Mortimer JA, Pedersen NL, Fratiglioni L, Johansson B, Gatz M. Work-related stress may increase the risk of vascular dementia. J Am Geriatr Soc 2012 Jan;60(1):60-7.

Bellander M, Brehmer Y, Westerberg H, Karlsson S, Fürth D, Bergman O, Eriksson E & Bäckman L. Preliminary evidence that allelic variation in the LMX1A gene influences training-related working memory improvement. Neuropsychologia, 2012;49:1938-1942.

Brehmer Y, Rieckmann A, Bellander M, Westerberg H, Fischer H & Bäckman L. Neural correlates of training-related working-memory gains in old age. Neuroimage, 2012;58:1110-1120.

Brodaty H, Breteler, DeKosky ST, Dorenlot P, Fratiglioni L, Hock C, Kenigsberg PA, Scheltens P, De Strooper B. The World of Dementia Beyond 2020. J Am Ger Soc 2011; 59(5): 923-927.

Bäckman L, Karlsson S, Fischer H, Karlsson P, Brehmer Y, Rieckmann A, MacDonald S W S, Farde L & Nyberg L. Dopamine D1 receptors and age differences in brain activation during working memory. Neurobiology of Aging, 2011;32:1849-1856.

Bäckman L, Nyberg L, Soveri A, Johansson J, Andersson M, Dahlin E, Neely A S, Virta J, Laine M & Rinne J O. Effects of working-memory training on striatal dopamine release. Science, 20111;333:718.

Edman A, Edenbrandt L, Fredén-Lindqvist J, Nilsson M, Wallin A. Asymmetric cerebral blood flow in patients with mild cognitive impairment: possible relationship to further cognitive deterioration.  Dement Geriatr Cogn Dis Extra. 2011 Jan;1(1):228-36.

Fratiglioni L, Qiu C. Prevention of cognitive decline in ageing: dementia as the target, delayed onset as the goal. Lancet Neurol. 2011; 10(9): 778-9.

Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E, Dodel R, Ekman M, Faravelli C, Fratiglioni L, Gannon B, Jones DH, Jennum P, Jordanova A, Jönsson L, Karampampa K, Knapp M, Kobelt G, Kurth T, Lieb R, Linde M, Ljungcrantz C, Maercker A, Melin B, Moscarelli M, Musayev A, Norwood F, Preisig M, Pugliatti M, Rehm J, Salvador-Carulla L, Schlehofer B, Simon R, Steinhausen HC, Stovner LJ, Vallat JM, den Bergh PV, van Os J, Vos P, Xu W, Wittchen HU, Jönsson B, Olesen J; CDBE2010Study Group. Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol. 2011 Oct;21(10):718-79.

Haasum Y, Fastbom J, Fratiglioni L, Kåreholt I, Johnell K. Pain treatment in elderly persons with and without dementia: a population-based study of institutionalized and home-dwelling elderly. Drugs Aging 2011 Apr 1;28(4):283-93.

Karlsson S, Rieckmann A, Karlsson P, Farde L, Nyberg L & Bäckman L. Relationship of dopamine D1 receptor binding in striatal and extrastriatal regions to cognitive functioning in healthy humans. Neuroimage, 2011:57:346-351.

Lilja A et al. Functional interaction of fibrillar and oligomeric amyloid-ß with alpha7 nicotinic receptors in Alzheimer´s disease. J Alzheimer Disease 2011; 23: 335-347.

Lindwall M, Larsman P & Hagger M S. The Reciprocal Relationship Between Physical Activity and Depression in Older European Adults: A Prospective Cross-Lagged Panel Design Using SHARE Data. Health Psychology, 2011;30:453-462.

MacDonald S W S, Karlsson S, Fratiglioni L & Bäckman L. Trajectories of cognitive decline following dementia onset: What accounts for variation in progression? Dementia and Geriatric Cognitive Disorders, 2011;31:202-209.

Mustafiz T et al. Characterization of the brain ß-amyloid isoform pattern at different ages of Tg 2576 mice. Neurodegener Dis 2011;8:352-63.

Piccinin AM, Muniz G, Matthews FE, Johansson B. Terminal decline from within- and between-person perspectives, accounting for incident dementia. J Gerontol B Psychol Sci Soc Sci. 2011;66(4):391-401.

Rieckmann A, Karlsson S, Fischer H & Bäckman L. Caudate dopamine D1 receptor density is associated with individual differences in fronto-parietal connectivity during working memory. Journal of Neuroscience, 2011;31:14284-14290.

Rieckmann A, Karlsson S, Karlsson P, Brehmer Y, Fischer H, Farde L, Nyberg L & Bäckman L. Dopamine D1 receptor associations within and between dopaminergic parhways in younger and elderly adults: Links to cognitive performance. Cerebral Cortex, 2011;21:2023-2032.

Rolstad S, Berg AI, Bjerke M, Blennow K, Johansson B, Zetterberg H, Wallin A. Amyloid-β₄₂ is associated with cognitive impairment in healthy elderly and subjective cognitive impairment. J Alzheimer’s Dis. 2011;26(1):135-42.

Schöll M et al. Time course of glucose metabolism in relation to cognitive performance and postmortem neuropathology in Met146ValPSEN1 mutation carriers. J Alzheimer’s Dis 2011;24:495-506.

The LADIS Study Group, Poggesi A, Pantoni L, Inzitari D, Fazekas F, Ferro J, O’Brien J, Hennerici M, Scheltens P, Erkinjuntti T, Visser M, Langhorne P, Chabriat H, Waldemar G, Wallin A, Wahlund A. 2001-2011: A Decade of the LADIS (Leukoaraiosis And DISability) Study: What Have We Learned about White Matter Changes and Small-Vessel Disease? Cerebrovasc Dis. 2011;32(6):577-588.

 

Vård och omsorgsforskning

(vård, rehabilitering, teknologi, primärvård, hälsoekonomi)

Brorsson A, Öhman A, Lundberg S & Nygård L. Accessibility in public space as perceived by people with Alzheimer’s disease. Dementia, 2011;10(4):587-602.

Edvardsson D, Fetherstonhaugh D, McAuliffe L, Chenco C & Nay R. Job satisfaction amongst aged care staff – exploring the influence of person-centred care provision. Int Psychoger 2011; 23, 1205-1212.

Edvardsson D, Fetherstonhaugh D & Nay R. The Tool for Understanding Residents’ Needs as Individual Persons (TURNIP): construction and initial testing. J Clin Nursing 2011;20, 2890-2896.

Hällgren M, Nygård L & Kottorp A. Technology and everyday functioning in people with intellectual disabilities: A Rasch analysis of the Everyday Technology Use Questionnaire (ETUQ). J Intellectual Disability Research, 2011;55(6):610-620.

Lövheim H, Gustafson Y, Karlsson S, Sandman PO.  Comparison of behavioral and psychological symptoms of dementia and psychotropic drug treatments among old people in geriatric care in 2000 and 2007. Int Psychoger 2011; 23:10,1616–1622

 

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